{"created":"2023-06-27T07:22:07.059510+00:00","id":1512,"links":{},"metadata":{"_buckets":{"deposit":"16a6a171-80b1-430d-9cfd-8c1909a5ca5b"},"_deposit":{"created_by":25,"id":"1512","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"1512"},"status":"published"},"_oai":{"id":"oai:shoin.repo.nii.ac.jp:00001512","sets":["9:10:265"]},"author_link":["660"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-06-20","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"20506307","subitem_description_type":"Other"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"神戸松蔭女子学院大学","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"23591385","subitem_description_type":"Other"}]},"item_10007_textarea_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"RUNX1の癌抑制遺伝子としての機能を解明することを目的として本研究を実施した。その結果、造血幹細胞において、RUNX1のC端欠失変異はDNA二重鎖切断への修復能を低下させることがわかった。また、RUNX1は、DNA損傷応答分子Gadd45aを転写レベルで制御していることがわかった。さらに、RUNX1のC端変異を有する骨髄異形成症候群患者では骨髄単核球中のGadd45の遺伝子発現量が低下していた。本研究を通してRUNX1は、DNA損傷、とくにDNA二重鎖切断からの修復過程に重要な働きを有しており、RUNX1の機能抑制型変異が、DNA損傷の蓄積と白血病の発症をもたらす可能性が考えられた。"},{"subitem_textarea_value":"We found that the C-terminal deletion mutant of RUNX1 attenuates DNA-damage repair responses in hematopoietic stem/progenitor cells. Bone marrow cells from MDS/AML patients harboring the RUNX1-C-terminal mutation showed significantly lower levels of GADD45A expression compared with those from MDS/AML patients with wild-type RUNX1. As for this mechanism, we found that RUNX1 directly regulates the transcription of GADD45A. These results suggest Gadd45a dysfunction due to RUNX1 mutations can cause additional mutation(s) required for multi-step leukemogenesis."}]},"item_10007_textarea_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_textarea_value":"科学研究費助成事業　研究成果報告書\n研究分担者:金倉譲[大阪大学]、織谷健司[大阪大学]"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-10-31"}],"displaytype":"detail","filename":"sato2014.pdf","filesize":[{"value":"74.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PDF","url":"https://shoin.repo.nii.ac.jp/record/1512/files/sato2014.pdf"},"version_id":"fc31e2bf-8362-40de-9598-4524d491fdf2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"RUNX1","subitem_subject_scheme":"Other"},{"subitem_subject":"MDS","subitem_subject_scheme":"Other"},{"subitem_subject":"AML","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA損傷","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 友亮"},{"creatorName":"SATOH, Yusuke"}],"nameIdentifiers":[{},{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ＤＮＡ修復経路におけるＲＵＮＸ１／ＡＭＬ１の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ＤＮＡ修復経路におけるＲＵＮＸ１／ＡＭＬ１の機能解析"},{"subitem_title":"Roles for RUNX1/AML1 in DNA damage-repair pathway","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"25","path":["265"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-25"},"publish_date":"2014-06-25","publish_status":"0","recid":"1512","relation_version_is_last":true,"title":["ＤＮＡ修復経路におけるＲＵＮＸ１／ＡＭＬ１の機能解析"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-06-27T07:53:16.052607+00:00"}